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Myositis Antibodies Profile Test in Ahmedabad, Gujarat | Myositis Autoantibodies Panel

Myositis is a disease of muscle where there is a problem with walking/standing properly due to inflammatory disorder of the muscles.

Qline Advanced Diagnostic Laboratory offer a Myositis Antibody Panel to help in the diagnosis of the idiopathic inflammatory myopathies, commonly referred to as myositis. When combined with clinical features, the myositis-specific autoantibodies can aid clinicians in making a diagnosis of myositis, polymyositis, dermatomyositis, anti-synthetase syndrome and related conditions. The Myositis Antibody Panel provides a quantitative in vitro assay for human antibodies present in serum and plasma of the IgG class to 16 different antigens.

Autoimmune Inflammatory Myopathies 16 Antigens :  ( Mi-2 alpha, Mi-2 beta, TIF1g, MDA5, NXP2, SAE1, Ku, PM-Scl100, PM-Scl75, Jo-1, SRP, PL-7, PL-12, EJ, OJ, Ro-52 Separately) – IgG antibodies detected separately by immunoblot method.

  • Result comes in 1-2 Days
  • Total Cost : Rs 8000
  • Time required in Lab : 10 minutes for blood collection
  • No special preparation required for the patient.
  • Report available whatsapp / email / courier

Antibodies to the sixteen common antigens are determined by an immunoblot profile assay. The color developed for each antigen is determined by densitometry and the intensity of the color is proportional to the antibody reactivity. The results are given in arbitrary intensity units

Antibody  Disease association
Jo-1 (Histidyl-tRNA Synthetase) Ab, IgG Polymyositis with associated interstitial lung disease, SLE, Systemic Sclerosis
Mi-2 (nuclear helicase protein) Antibody Dermatomyositis
PL-7 (threonyl-tRNA synthetase) Antibody Myositis (PM, DM) with associated interstitial lung disease, SLE, Systemic Sclerosis
PL-12 (alanyl-tRNA synthetase) Antibody Myositis (PM, DM)
EJ (glycyl-tRNA synthetase) Antibody Polymyositis
SRP (Signal Recognition Particle) Ab Polymyositis & dermatomyositis
OJ (isoleucyl-tRNA synthetase) Antibody Polymyositis
SAE1 (SUMO activating enzyme) Ab DM & DM asso. Interstitial Lung Disease
MDA5 (CADM-140) Ab Dermatomyositis
NXP2 (Nuclear matrix protein-2) Ab Juvenile Myositis (PM/DM)
TIF-1 gamma (transcriptional intermediary factor 155 kDa) Ab Dermatomyositis, Cancer associated Myositis
Anti-Ku Ab Autoimmune Myositis
PM scl -100/75 (anti-exosome) Ab PolyMyositis, Dermatomyositis & Systemic sclerosis
SSA/RO-52 (Anti-Sjögren’s-syndrome-related antigen A) ab Myositis (PM, DM), other rheumatic diseases
SAE-2 (SUMO activating enzyme) Ab Autoimmune Myositis

myositis specific antibodiesmyositis autoantibodies

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

TEST INTERPRETATION
Results
Positive: as a single test, not diagnostic for inflammatory myopathy
Negative: does not rule out inflammatory myopathy

Limitations
Results by themselves are not diagnostic; strong clinical correlation is recommended
Negative results do not rule out a diagnosis of inflammatory myopathy or overlap syndrome

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